[KO Validated] Caspase-3 Rabbit mAb,ABclonal,A19654
Reactivity
Human, Mouse
Application
WB, ELISA
Conjugate
Unconjugated
Platform ID
BAB968859306
ABclonal
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Product Specifications
Scientific Background
Synonyms
Specifications
Name[KO Validated] Caspase-3 Rabbit mAb
Cat. No.A19654
Accession NumberP42574
Gene ID (Entrez)836
RRIDAB_2862718
IsotypeIgG
ReactivityHuman, Mouse
ConjugationUnconjugated
ApplicationWB, ELISA
Working DilutionsWB:1:1000 - 1:2000 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Clone NumberARC0133
Molecular Weight17kDa/32kDa
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Regulatory StatusResearch Use Only
Scientific Background
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Synonyms
CPP32; SCA-1; CPP32B; -3
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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