[KO Validated] HDAC1 Rabbit mAb,ABclonal,A26492

Reactivity

Human, Mouse

Application

WB, IP, IF/ICC, IF-P, IHC-P, ChIP, ELISA

Conjugate

Unconjugated

Platform ID

BAB468709378

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

Tel:
Fax:

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Name[KO Validated] HDAC1 Rabbit mAb
Cat. No.A26492
Accession NumberQ13547
Gene ID (Entrez)3065
IsotypeIgG
ReactivityHuman, Mouse
ConjugationUnconjugated
ApplicationWB, IP, IF/ICC, IF-P, IHC-P, ChIP, ELISA
Working DilutionsWB:1:5000 - 1:25000 | IP:0.5μg-4μg antibody for 200μg-400μg extracts of whole cells | IF/ICC:1:2000 - 1:8000 | IF-P:1:2000 - 1:8000 | IHC-P:1:5000 - 1:20000 | ChIP:2-3μg antibody for 10μg-25μg of Chromatin | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Clone NumberARC70626
Molecular Weight65 kDa
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Regulatory StatusResearch Use Only

Scientific Background

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Synonyms

HD1; RPD3; KDAC1; GON-10; RPD3L1

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