[KO Validated] MKL1 Rabbit mAb,ABclonal,A28574

Reactivity

Human, Mouse, Rat

Application

WB, IP, IHC-P, ELISA

Conjugate

Unmodified

Platform ID

BAB032839845

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

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Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Name[KO Validated] MKL1 Rabbit mAb
Cat. No.A28574
Accession NumberQ969V6
Gene ID (Entrez)57591
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnmodified
ApplicationWB, IP, IHC-P, ELISA
Working DilutionsWB:1:6000 - 1:50000 | IP:0.5 μg - 4 μg antibody for 800 μg - 1200 μg extracts of whole cells | IHC-P:1:200 - 1:800 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.For high-ratio antibody dilutions (≥1:10000)a sequential dilution method is strongly recommended to ensure measurement accuracy.
Clone NumberARC78147
Molecular Weight145 kDa
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants.

Synonyms

MAL; MKL; BSAC; MKL1; MRTF-A

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