[KO Validated] SIRT1 Rabbit mAb,ABclonal,A27256

Reactivity

Human, Mouse, Rat

Application

WB, IF/ICC, IF-P, IHC-P, FC (intra), ELISA

Conjugate

Unconjugated

Platform ID

BAB031240613

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

Tel:
Fax:

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Name[KO Validated] SIRT1 Rabbit mAb
Cat. No.A27256
Accession NumberQ96EB6
Gene ID (Entrez)23411
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB, IF/ICC, IF-P, IHC-P, FC (intra), ELISA
Working DilutionsWB:1:1000 - 1:4000 | IF/ICC:1:100 - 1:400 | IF-P:1:100 - 1:400 | IHC-P:1:100 - 1:500 FC (intra)1:50 - 1:200 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Clone NumberARC3323
Molecular Weight110 kDa/120 kDa
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Regulatory StatusResearch Use Only

Scientific Background

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Synonyms

SIR2; SIR2L1; SIR2alpha

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