[KO Validated] SIRT1 Rabbit mAb,ABclonal,A19667

Reactivity

Human

Application

WB, IF/ICC, ELISA

Conjugate

Unconjugated

Platform ID

BAB718434510

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

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Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Name[KO Validated] SIRT1 Rabbit mAb
Cat. No.A19667
Accession NumberQ96EB6
Gene ID (Entrez)23411
RRIDAB_2862725
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationWB, IF/ICC, ELISA
Working DilutionsWB:1:1000 - 1:4000 | IF/ICC:1:50 - 1:200 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Clone NumberARC0146
Molecular Weight130kDa
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 648-747 of human SIRT1 (Q96EB6).
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Regulatory StatusResearch Use Only

Scientific Background

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.

Synonyms

SIR2; SIR2L1; SIR2alpha; T1

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