[KO Validated] c-Myc Rabbit mAb,ABclonal,A19032

Reactivity

Human

Application

WB, ELISA, ChIP, CUT&Tag

Conjugate

Unconjugated

Platform ID

BAB406128167

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

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Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

Name[KO Validated] c-Myc Rabbit mAb
Cat. No.A19032
Accession NumberP01106
Gene ID (Entrez)4609
RRIDAB_2862524
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationWB, ELISA, ChIP, CUT&Tag
Working DilutionsWB:1:1000 - 1:2000 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. | ChIP:5μg antibody for 10μg-15μg of Chromatin | CUT&Tag:10⁵ cells /1 μg
Clone NumberARC0412
Molecular Weight50-60kDa
ImmunogenSynthetic peptide. This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Regulatory StatusResearch Use Only

Scientific Background

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

Synonyms

MRTL; MYCC; c-Myc; bHLHe39; yc

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