KSHV GPCR antibody,Genetex,GTX45122

Host

Rabbit

Reactivity

Kaposi's sarcoma-associated herpesvirus

Application

FCM

Conjugate

Unconjugated

Platform ID

BAB159657794

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameKSHV GPCR antibody
Cat. No.GTX45122
HostRabbit
IsotypeIgG
ReactivityKaposi's sarcoma-associated herpesvirus
ConjugationUnconjugated
ApplicationFCM
ClonalityPolyclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
ImmunogenRecombinant fragment - amino acids 1-41 of HHV8 GPCR (N-terminal)
PurityProtein A affinity purifiedFrom polyclonal serum
Appearance/FormLiquid
FormulationPBS,0.1% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Kaposi's sarcoma-associated herpesvirus (KSHV, or human herpesvirus 8, HHV8), is a gamma herpesvirus that contain an open reading frame encoding a G protein-coupled receptor (GPCR) with putative 7 transmembrane domains. This GPCR has been shown to bind a number of chemokines including IL8, NAP2, PF4, MGSA/Gro alpha, I309, RANTES, MCP1, and MIP1 beta. The receptor is constitutively activated without chemokine binding, and it stimulates cell proliferation. KSHV GPCR is also a viral oncogene that stimulates angio-genesis through induction of VEGF expression. IP10, a chemokine, can inhibit constitutively activated KSHV GPCR.

Synonyms

Kaposi's sarcoma-associated herpesvirus GPCR , HHV-8 GPCR , Human herpesvirus 8 GPCR

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