Ki67 Antibody (YA4035),MedChemexpress,HY-P84338
Ki67 Antibody (YA4035) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Ki67.
Host
Mouse
Reactivity
Human,Mouse,Rat,Rabbit,Monkey
Application
WB,IHC-P,FC,ELISA
Conjugate
Non-conjugated
Platform ID
BAB338087510
Suppliers
(1)Biomedical Life sciences
MedChemexpress
Master of Bioactive Molecules
Contact
Tel: 609-228-6898
Fax: 609-228-5909
Email:
Specifications
Scientific Background
Ki67 is a protein that binds to the surface of mitotic chromosomes, functioning as a chromosome repellent during early mitosis and switching to a chromosome attractant in late mitosis. It maintains dispersed chromosome structures by forming an electrostatically charged brush-like barrier, preventing chromatin aggregation. During anaphase, Ki67 undergoes structural collapse and promotes chromosome clustering via RNA-dependent liquid-liquid phase separation, facilitating cytoplasmic particle exclusion from the nascent nuclear space. It exhibits DNA-binding specificity for supercoiled and AT-rich regions, interacts with premature rRNAs, and may influence chromatin organization (mechanistically debated). Note: Its contribution to internal mitotic chromosome architecture remains unconfirmed (by similar).
Synonyms
KIA; Ki-67; MKI67
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>IHC Antibodies
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