LAMC1 Antibody#92921,Cell Signaling Technology (CST),92921

Laminins are a family of proteins important for maintaining cellular basement membrane (BM) structure and function (1). Laminins exist as heterotrimers of alpha (LAMA), beta (LAMB), and gamma (LAMC) chains. LAMC1 (laminin gamma-1) is a ubiquitously expressed gamma chain, and has three distinct functional domain structures. The N-terminal LN domain binds to specific alpha and beta chains to form a unique laminin heterotrimer. The LE domain mediates interactions with nidogens, while the C-terminal coil-coil fragment is necessary for agrin association. Collectively, these interactions are critical for stabilization and function of the BM (1). Genetic ablation of LAMC1 has demonstrated a critical role for this protein in embryo implantation, lung and kidney development, and neuronal Schwann cell myelination and regeneration, in addition to Trypanosome infection (2-5). Upregulation of LAMC1 has also been associated with tumor progression in multiple tumor types (6-9), possibly by creating a BM environment that is favorable for cancer cell metastasis and invasion.Yurchenco, P.D. (2011)Cold Spring Harb Perspect Biol3, a004911.Ramathal, C. et al. (2011)J Biol Chem286, 19860-71.Willem, M. et al. (2002)Development129, 2711-22.Chen, Z.L. and Strickland, S. (2003)J Cell Biol163, 889-99.Nde, P.N. et al. (2012)Front Immunol3, 337.Liétard, J. et al. (1997)Am J Pathol151, 1663-72.Nishikawa, R. et al. (2014)Int J Oncol45, 401-10.Huang, S.X. et al. (2016)Int J Oncol49, 217-24.Kashima, H. et al. (2015)Gynecol Oncol139, 338-44.Alternate NamesLAMB2; LAMC1; Laminin B2 chain; laminin subunit gamma 1; Laminin subunit gamma-1; Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit gamma; laminin, gamma 1 (formerly LAMB2); MGC87297; S-LAM gamma; S-laminin subunit gamma

LAMB2; LAMC1; Laminin B2 chain; laminin subunit gamma 1; Laminin subunit gamma-1; Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit gamma; laminin, gamma 1 (formerly LAMB2); MGC87297; S-LAM gamma; S-laminin subunit gamma