LAMP1 (D2D11) Rabbit Monoclonal Antibody (SignalFlexTMmFluorTMViolet 510 Conjugate)#69796,Cell Signaling Technology (CST),69796

LAMP1 (D2D11) XP®Rabbit mAb (SignalFlexTM mFluorTM Violet 510 Conjugate) recognizes endogenous levels of total LAMP1 protein.

Host

Rabbit

Reactivity

Human, Monkey

Conjugate

SignalFlexTMmFluorTMViolet 510 Conjugate

Platform ID

BAB011227695

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameLAMP1 (D2D11) Rabbit Monoclonal Antibody (SignalFlexTMmFluorTMViolet 510 Conjugate)#69796
Cat. No.69796
Accession NumberP11279
Gene ID (Entrez)11279, 3916
HostRabbit
SensitivityEndogenous
ReactivityHuman, Monkey
ConjugationSignalFlexTMmFluorTMViolet 510 Conjugate
ImmunogenIgG
FormulationSignalFlexTM conjugates are produced using highly validated Cell Signaling Technology®primary antibodies and conjugation methods that have been rigorously tested, ensuring high-quality conjugates and lot-to-lot consistency. These conjugates are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity. However, they are not tested on specific assays.Optimal dilutions/concentrations should be determined by the end user. When performing flow cytometry, we recommend using an isotype control conjugate at the same concentration as the antibody conjugate.
StorageSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C.Do not aliquot the antibody. Protect from light. Do not freeze.
Regulatory StatusResearch Use Only

Scientific Background

Lysosome-associated membrane protein 1 and 2 (LAMP1 and LAMP2) are two abundant lysosomal membrane proteins (1,2). Both are transmembrane proteins and are heavily glycosylated at the amino-terminal luminal side of the lysosomal inner leaflet, which protects the proteins from proteolysis (3). The carboxy terminus of LAMP1 is exposed to the cytoplasm and contains a tyrosine sorting motif that targets LAMP to lysosomal membranes (4). LAMP1 and LAMP2 are 37% homologous in their protein sequences. Both LAMP1 and LAMP2 are involved in regulating lysosomal motility during lysosome-phagosome fusion and cholesterol trafficking (5,6).Eskelinen, E.L. et al. (2003)Trends Cell Biol13, 137-45.Fukuda, M. (1991)J Biol Chem266, 21327-30.Kundra, R. and Kornfeld, S. (1999)J Biol Chem274, 31039-46.Rohrer, J. et al. (1996)J Cell Biol132, 565-76.Huynh, K.K. et al. (2007)EMBO J26, 313-24.Eskelinen, E.L. et al. (2004)Mol Biol Cell15, 3132-45.Alternate NamesCD107 antigen-like family member A; CD107a; LAMP-1; LAMP1; LAMPA; LGP120; lysosomal associated membrane protein 1; lysosomal-associated membrane protein 1; Lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane protein 1

Synonyms

CD107 antigen-like family member A; CD107a; LAMP-1; LAMP1; LAMPA; LGP120; lysosomal associated membrane protein 1; lysosomal-associated membrane protein 1; Lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane protein 1

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