LXR alpha Recombinant Antibody,Bioss,bsm-54023r-100ul

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB, FCM, IF(ICC)

Conjugate

Unconjugated

Platform ID

BAB156556524

Bioss

Headquarters

300 Tradecenter Dr, ste 4610Woburn, Massachusetts 01801 - U.S.A.

Bioss

Contact

Tel: +1.781.569.5821
Fax: +1.781.731.9286

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameLXR alpha Recombinant Antibody
Cat. No.bsm-54023r-100ul
Accession NumberQ13133
Gene ID (Entrez)10062
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB, FCM, IF(ICC)
Working DilutionsWB:1:500-2000 | FCM:FCM1:50-100 | IF(ICC):IFICC1:50-200
ClonalityMonoclonal
ConcentrationLot Dependent
PurityPurified by Protein A.
Formulation0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
StorageShipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Scientific Background

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism.

Synonyms

Oxysterols receptor LXR-alpha; LXR alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3; NR1H3; LXRA; RLD-1.

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