LYVE-1 (E3L3V) Rabbit Monoclonal Antibody (Alexa Fluor^®488 Conjugate)#69240,Cell Signaling Technology (CST),69240

Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), also known as extracellular link domain-containing protein 1 (XLKD1), is a type I integral membrane glycoprotein. LYVE-1 is a CD44 homolog found primarily on lymphatic endothelial cells, but has also been described on hepatic blood sinusoidal endothelia, embryonic blood vessels, Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium (1-3). LYVE-1 acts as a receptor for hyaluronan, and plays a role in hyaluronan transport and turnover (4-7). LYVE-1 also mediates the docking and entry of dendritic cells to lymphatic vessels through selective adhesion to hyaluronan in the leukocyte surface glycocalyx (8). Several studies have demonstrated the utility of LYVE-1 as a marker for lymphoid tissues and lymphangiogenesis (9,10).Mouta Carreira, C. et al. (2001)Cancer Res61, 8079-84.Lee, H.W. et al. (2011)Cell Tissue Res343, 429-44.Gordon, E.J. et al. (2008)Dev Dyn237, 1901-9.Banerji, S. et al. (1999)J Cell Biol144, 789-801.Lawrance, W. et al. (2016)J Biol Chem291, 8014-30.Prevo, R. et al. (2001)J Biol Chem276, 19420-30.Stanly, T.A. et al. (2020)J Biol Chem295, 5036-5050.Johnson, L.A. et al. (2017)Nat Immunol18, 762-770.Skobe, M. et al. (2001)Nat Med7, 192-8.Beasley, N.J. et al. (2002)Cancer Res62, 1315-20.Alternate Names1200012G08Rik; cell surface retention sequence binding protein-1; Cell surface retention sequence-binding protein 1; CRSBP-1; Crsbp1; extra cellular link domain-containing 1; Extracellular link domain-containing protein 1; lymphatic vessel endothelial HA receptor-1; lymphatic vessel endothelial HA recptor-1; lymphatic vessel endothelial hyaluronan receptor 1; Lymphatic vessel endothelial hyaluronic acid receptor 1; Lyve; LYVE-1; Lyve1; Xlkd; Xlkd1

1200012G08Rik; cell surface retention sequence binding protein-1; Cell surface retention sequence-binding protein 1; CRSBP-1; Crsbp1; extra cellular link domain-containing 1; Extracellular link domain-containing protein 1; lymphatic vessel endothelial HA receptor-1; lymphatic vessel endothelial HA recptor-1; lymphatic vessel endothelial hyaluronan receptor 1; Lymphatic vessel endothelial hyaluronic acid receptor 1; Lyve; LYVE-1; Lyve1; Xlkd; Xlkd1