Lamin A/C (4C11) Mouse Monoclonal Antibody (Biotinylated)#54106,Cell Signaling Technology (CST),54106

Lamin A/C (4C11) Mouse Monoclonal Antibody (Biotinylated) detects endogenous levels of lamin A and lamin C proteins. This antibody also reacts with the larger fragments of lamin A (50 kDa) and lamin C (41 kDa) produced by caspase cleavage during apoptosis. This antibody does not cross-react with lamins B1 and B2.

Host

Mouse

Reactivity

Human, Mouse, Rat, Monkey

Application

Western Blotting: 1:1000

Platform ID

BAB323633990

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameLamin A/C (4C11) Mouse Monoclonal Antibody (Biotinylated)#54106
Cat. No.54106
Accession NumberP02545
Gene ID (Entrez)02545, 4000
HostMouse
SensitivityEndogenous
ReactivityHuman, Mouse, Rat, Monkey
ApplicationWestern Blotting: 1:1000
Molecular Weight74 (Lamin A), 63 (Lamin C)
ImmunogenIgG2a
FormulationSupplied in 140 mM NaCl, 3 mM KCI, 10 mM sodium phosphate (pH 7.4) dibasic, 2 mM potassium phosphate monobasic, 2 mg/mL BSA, and 50% glycerol. Store at –20°C.Do not aliquot the antibody.
StorageSupplied in 140 mM NaCl, 3 mM KCI, 10 mM sodium phosphate (pH 7.4) dibasic, 2 mM potassium phosphate monobasic, 2 mg/mL BSA, and 50% glycerol. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization (1-3). Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment (3,4). The cleavage of lamins results in nuclear dysregulation and cell death (5,6).Gruenbaum, Y. et al. (2000)J Struct Biol129, 313-23.Yabuki, M. et al. (1999)Physiol Chem Phys Med NMR31, 77-84.Goldberg, M. et al. (1999)Crit Rev Eukaryot Gene Expr9, 285-93.Orth, K. et al. (1996)J Biol Chem271, 16443-6.Oberhammer, F.A. et al. (1994)J Cell Biol126, 827-37.Rao, L. et al. (1996)J Cell Biol135, 1441-55.Alternate Names70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; epididymis secretory sperm binding protein; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A/C; lamin A/C-like 1; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; MADA; mandibuloacral dysplasia type A; Prelamin-A/C; PRO1; Renal carcinoma antigen NY-REN-32

Synonyms

70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; epididymis secretory sperm binding protein; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A/C; lamin A/C-like 1; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; MADA; mandibuloacral dysplasia type A; Prelamin-A/C; PRO1; Renal carcinoma antigen NY-REN-32

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