Leptin antibody,Genetex,GTX37638

Host

Rabbit

Reactivity

Human, Rat

Application

WB IHC-P

Conjugate

Unconjugated

Platform ID

BAB459370185

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameLeptin antibody
Cat. No.GTX37638
Gene ID (Entrez)3952
HostRabbit
IsotypeIgG
ReactivityHuman, Rat
ConjugationUnconjugated
ApplicationWB IHC-P
ClonalityPolyclonal
Concentration0.5 mg/ml (Please refer to the vial label for the specific concentration.)
TargetLEP
ImmunogenKLH conjugated synthetic peptide derived between 27-90 amino acids of human Leptin
PurityProtein A purified
Appearance/FormLiquid
Formulation10mM TBS, 0.5% BSA, 25% Glycerol,0.015% ProClin 300
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Aug 2017]

Synonyms

leptin , LEPD , OB , OBS

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