Lysophospholipid (LPA) Receptor Antibody Explorer Kit,Alomone Labs,AK-515_KIT

Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycerol-3-phosphate) is a bioactive lipid molecule with a phosphate, a glycerol, and a fatty acid in its structure. The cellular effects of LPA include proliferation, migration, cytokine secretion, and morphological change. These pleiotropic actions allow LPA to participate in a wide variety of biological processes, such as brain development, oncogenesis, wound healing and cancer progression 1 . To date, at least 6 subtypes of LPA receptor have been identified. The LPA1-3 receptors are members of the endothelial cell differentiation gene (Edg) family 2 . LPA6 (P2Y5) was cloned as an orphan GPCR and is closely related to the fourth lysophosphatidic acid receptor, LPA4 3 . GPCRs share a similar topology, with seven transmembrane helices (TMHs) connected by three extracellular loops (ECLs), and three intracellular loops (ICLs); the N terminus is on the extracellular side of the membrane, and the C terminus is on the cytoplasmic side 4 . LPA6 mRNA is expressed ubiquitously including in skin and hair follicle cells. A recent study suggested that LPA6 is essential for human hair growth. A loss of function is not compensated for, and ultimately leads to pathological changes and hair loss 5 .