MAOA Antibody#66935,Cell Signaling Technology (CST),66935

MAOA Antibody recognizes endogenous levels of total MAOA protein.

Reactivity

Human

Application

Western Blotting: 1:1000

Platform ID

BAB548659719

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameMAOA Antibody#66935
Cat. No.66935
Accession NumberP21397
Gene ID (Entrez)21397, 4128
SensitivityEndogenous
ReactivityHuman
ApplicationWestern Blotting: 1:1000
Molecular Weight62
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Monoamine oxidase A (MAOA), a mitochondrial enzyme, catalyzes the degradation of monoamines. Studies show that increased expression of MAOA promotes prostate cancer metastasis by activating the Shh-IL6-RANKL signaling network (1). In addition, MAOA expression in adipose tissue macrophages is upregulated in aging, leading to the reduction of noradrenaline availability in adipose tissue. Decreased levels of noradrenaline contribute to the aging-related decline of catecholamine-induced lipolysis in adipocytes (2). Furthermore, sympathetic neuron–associated macrophages import and degrade norepinephrine via the transporter SLC6A2 and MAOA, respectively, and thus contribute to obesity (3).Wu, J.B. et al. (2017)Cancer Cell31, 368-82.Camell, C.D. et al. (2017)Nature550, 119-23.Pirzgalska, R.M. et al. (2017)Nat Med23, 1309-18.Alternate NamesAmine oxidase [flavin-containing] A; AOFA; BRNRS; MAO-A; MAOA; Monoamine oxidase; monoamine oxidase A; Monoamine oxidase type A

Synonyms

Amine oxidase [flavin-containing] A; AOFA; BRNRS; MAO-A; MAOA; Monoamine oxidase; monoamine oxidase A; Monoamine oxidase type A

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