MAP4K3 (E9L1J) Rabbit Monoclonal Antibody#69387,Cell Signaling Technology (CST),69387

MAP4K3 (E9L1J) Rabbit Monoclonal Antibody recognizes endogenous levels of total MAP4K3 protein. A band of unknown identity is detected at 48 kDa.

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

Western Blotting: 1:1000 Immunoprecipitation: 1:200

Platform ID

BAB298734683

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameMAP4K3 (E9L1J) Rabbit Monoclonal Antibody#69387
Cat. No.69387
Accession NumberQ99JP0, 225028
Gene ID (Entrez)225028
HostRabbit
SensitivityEndogenous
ReactivityHuman, Mouse, Rat
ApplicationWestern Blotting: 1:1000 Immunoprecipitation: 1:200
Molecular Weight101
ImmunogenIgG
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

The mTORC1 kinase complex is a critical regulator of cell growth (1,2). Its activity is modulated by growth factors and nutrients including amino acids (1,2). MAP4K3 is a mediator between nutrient signal and mTORC1 (1). Research studies suggest that amino acid sufficiency leads to the phosphorylation of Ser170 on MAP4K3, which activates mTORC1 (3).Findlay, G.M. et al. (2007)Biochem J403, 13-20.Sancak, Y. et al. (2008)Science320, 1496-501.Yan, L. et al. (2010)Mol Cell37, 633-42.Alternate Names4833416M01Rik; 4833416M07Rik; 9530052P13Rik; germinal center kinase-like kinase-like; Germinal center kinase-related protein kinase; GLK; KHS2; M4K3; Map4k3; MAPK/ERK kinase kinase kinase 3; MAPKKKK3; MEK kinase kinase 3; MEKKK 3; MEKKK3; mitogen activated protein kinase kinase kinase kinase 3; Mitogen-activated protein kinase kinase kinase kinase 3; RAB8IPL1

Synonyms

4833416M01Rik; 4833416M07Rik; 9530052P13Rik; germinal center kinase-like kinase-like; Germinal center kinase-related protein kinase; GLK; KHS2; M4K3; Map4k3; MAPK/ERK kinase kinase kinase 3; MAPKKKK3; MEK kinase kinase 3; MEKKK 3; MEKKK3; mitogen activated protein kinase kinase kinase kinase 3; Mitogen-activated protein kinase kinase kinase kinase 3; RAB8IPL1

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