MDM2 antibody [SMP14],Genetex,GTX70278

Host

Mouse

Reactivity

Human, Mouse

Application

WB IHC-P IHC-Fr IP IHC (Resin sections)

Conjugate

Unconjugated

Platform ID

BAB047277969

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameMDM2 antibody [SMP14]
Cat. No.GTX70278
Gene ID (Entrez)4193
HostMouse
IsotypeIgG1
ReactivityHuman, Mouse
ConjugationUnconjugated
ApplicationWB IHC-P IHC-Fr IP IHC (Resin sections)
ClonalityMonoclonal
Concentration1.0 mg/ml (Please refer to the vial label for the specific concentration.)
TargetMDM2
ImmunogenSynthetic peptide, CSRPSTSSRRRAISE, corresponding to amino acids 154-167 of human MDM2
PurityProtein G purified
Appearance/FormLiquid
FormulationPBS,0.09% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]

Synonyms

MDM2 proto-oncogene , ACTFS , HDMX , hdm2

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