MDR1/ABCB1 (E1Y7S) Rabbit Monoclonal Antibody#13978,Cell Signaling Technology (CST),13978

MDR1/ABCB1 belongs to the Mdr/Tap subfamily of the ATP-binding cassette transporter superfamily (1). Multidrug resistance 1 (MDR1) serves as an efflux pump for xenobiotic compounds with broad substrate specificity. MDR1 substrates include therapeutic agents such as actinomycin D, etoposide, imatinib, and doxorubicin, as well as endogenous molecules including β-amyloids, steroid hormones, lipids, phospholipids, cholesterol, and cytokines (2). Research studies have shown that MDR1 reduces drug accumulation in cancer cells, allowing the development of drug resistance (3-5). On the other hand, MDR1 expressed in the plasma membrane of cells in the blood-brain, blood-cerebral spinal fluid, or blood-placenta barriers restricts the permeability of drugs into these organs from the apical or serosal side (6,7). MDR1 is also expressed in normal tissues with excretory function such as small intestine, liver, and kidney (7). Intracellular MDR1 has been detected in the ER, vesicles, and nuclear envelope, and has been associated with cell trafficking machinery (8). Other reported functions of MDR1 include viral resistance, cytokine trafficking (9,10), and lipid homeostasis in the peripheral and central nervous system (11-13).Furuya, K.N. et al. (1997)Cancer Res57, 3708-16.Litman, T. et al. (1997)Biochim Biophys Acta1361, 169-76.Chen, C.J. et al. (1986)Cell47, 381-9.Kartner, N. et al. (1983)Cancer Res43, 4413-9.Chen, G. et al. (1997)J Biol Chem272, 5974-82.Brinkmann, U. and Eichelbaum, M. (2001)Pharmacogenomics J1, 59-64.Fromm, M.F. (2004)Trends Pharmacol Sci25, 423-9.Miller, D.S. et al. (2008)Pharmacol Rev60, 196-209.Ambudkar, S.V. et al. (1999)Annu Rev Pharmacol Toxicol39, 361-98.Raviv, Y. et al. (2000)FASEB J14, 511-5.Meijer, O.C. et al. (2003)J Endocrinol178, 13-8.Karssen, A.M. et al. (2002)J Endocrinol175, 251-60.Jeannesson, E. et al. (2009)Clin Chim Acta403, 198-202.Alternate NamesABC20; ABCB1; ATP binding cassette subfamily B member 1; ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, subfamily B, member 1; ATP-dependent translocase ABCB1; CD243; CLCS; colchicin sensitivity; doxorubicin resistance; GP170; MDR1; MGC163296; Multidrug resistance protein 1; P-glycoprotein 1; P-GP; PGY1; Phospholipid transporter ABCB1

ABC20; ABCB1; ATP binding cassette subfamily B member 1; ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, subfamily B, member 1; ATP-dependent translocase ABCB1; CD243; CLCS; colchicin sensitivity; doxorubicin resistance; GP170; MDR1; MGC163296; Multidrug resistance protein 1; P-glycoprotein 1; P-GP; PGY1; Phospholipid transporter ABCB1