MGMT Rabbit mAb,ABclonal,A23520

Reactivity

Human

Application

WB, IHC-P, IF/ICC, ELISA

Conjugate

Unconjugated

Platform ID

BAB536488093

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

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Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameMGMT Rabbit mAb
Cat. No.A23520
Accession NumberP16455
Gene ID (Entrez)4255
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationWB, IHC-P, IF/ICC, ELISA
Working DilutionsWB:1:10000 - 1:40000 | IHC-P:1:50 - 1:200 | IF/ICC:1:50-1:200 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Clone NumberARC55549
Molecular Weight22kDa
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
PurityAffinity purification
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Regulatory StatusResearch Use Only

Scientific Background

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.

Synonyms

MGMT; O-6-methylguanine-DNA methyltransferase

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