MIP3 alpha antibody,Genetex,GTX48690

Host

Rabbit

Reactivity

Mouse, Rat

Application

WB ELISA

Conjugate

Unconjugated

Platform ID

BAB863143867

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Product Specifications
Scientific Background
Synonyms

Specifications

NameMIP3 alpha antibody
Cat. No.GTX48690
Gene ID (Entrez)20297
HostRabbit
IsotypeIgG
ReactivityMouse, Rat
ConjugationUnconjugated
ApplicationWB ELISA
ClonalityPolyclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetCcl20
ImmunogenFull length recombinant mouse MIP-3 alpha protein.
PurityProtein A purified
Appearance/FormLiquid
Formulation20mM Potassium Phosphate, 150mM NaCl,No preservatives
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

MIP-3a (also known as C-C motif chemokine 20, small-inducible cytokine A20, macrophage inflammatory protein 3 alpha, MIP-3-alpha, liver and activation-regulated chemokine, CC chemokine LARC and beta chemokine exodus-1) is a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. MIP-3a inhibits proliferation of myeloid progenitors in colony formation assays and may be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. MIP-3a also possesses antibacterial activity against E.coli and S.aureus. MIP-3a is a secreted protein that is expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels of expression are also seen in thymus, prostate, testis, small intestine and colon. C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Synonyms

chemokine (C-C motif) ligand 20 , CKb4 , LARC , MIP-3A , MIP-3[a] , MIP3A , ST38 , Scya20 , exodus-1

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