MITF (D5G7V) Rabbit Monoclonal Antibody#12590,Cell Signaling Technology (CST),12590

Microphthalmia-associated transcription factor (MITF) is a basic helix-loop-helix leucine zipper transcription factor that is most widely known for its roles in melanocyte, ophthalmic, and osteoclast development (1-3). In humans, MITF can function as a melanoma oncogene (4) and mutations in the correspondingMITFgene are associated with Waardenburg syndrome type 2, an auditory-pigmentary syndrome characterized by developmental defects in cells derived from neural crest (5). At least 12 isoforms of MITF have been identified, which exhibit differential patterns of expression among cell and tissue types (6).Hershey, C.L. and Fisher, D.E. (2004)Bone34, 689-96.Nomura, S. et al. (2001)J Bone Miner Metab19, 183-7.Widlund, H.R. and Fisher, D.E. (2003)Oncogene22, 3035-41.Levy, C. et al. (2006)Trends Mol Med12, 406-14.Read, A.P. and Newton, V.E. (1997)J Med Genet34, 656-65.Tachibana, M. (2000)Pigment Cell Res13, 230-40.Alternate NamesBHLHE32; Class E basic helix-loop-helix protein 32; CMM8; COMMAD; homolog of mouse microphthalmia; melanocyte inducing transcription factor; melanogenesis associated transcription factor; MI; microphtalmia-associated transcription factor; Microphthalmia-associated transcription factor; microphthalmia-associated transcription factor-M transcript; MITF; WS2; WS2A

BHLHE32; Class E basic helix-loop-helix protein 32; CMM8; COMMAD; homolog of mouse microphthalmia; melanocyte inducing transcription factor; melanogenesis associated transcription factor; MI; microphtalmia-associated transcription factor; Microphthalmia-associated transcription factor; microphthalmia-associated transcription factor-M transcript; MITF; WS2; WS2A