MLH1 antibody [IHC409],Genetex,GTX57187

This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009]

Mutl Homolog 1 , Coca2 , Fcc2 , Hnpcc , Hnpcc2 , Hmlh1 , Mlh1