MMP-8 (E1C4L) Rabbit Monoclonal Antibody#78399,Cell Signaling Technology (CST),78399

The matrix metalloproteinases (MMPs) are a family of proteases that target many extracellular proteins including other proteases, growth factors, cell surface receptors, and adhesion molecules (1). Among the family members, MMP-2, MMP-3, MMP-7, and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis, and apoptosis (2-4). Research studies have shown that MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full-length protein (5). MMP-8 is also known as Neutrophil Collagenase as it is stored in special granules in neutrophils. Like other MMPs, it also cleaves fibrillar collagens. It also is implicated in various cancers and is thought to be pro-tumorigenic (6).McCawley, L.J. and Matrisian, L.M. (2001)Curr Opin Cell Biol13, 534-40.Coussens, L.M. et al. (2002)Science295, 2387-92.Sternlicht, M.D. et al. (1999)Cell98, 137-46.Vu, T.H. et al. (1998)Cell93, 411-22.Nagase, H. et al. (1990)Biochemistry29, 5783-9.Juurikka, K. et al. (2019)Int J Mol Sci20, .Alternate NamesCLG1; collagenase 2; HNC; matrix metallopeptidase 8; matrix metallopeptidase 8 (neutrophil collagenase); matrix metalloproteinase 8; matrix metalloproteinase 8 (neutrophil collagenase); Matrix metalloproteinase-8; MMP-8; MMP8; Neutrophil collagenase; PMN leukocyte collagenase; PMNL collagenase; PMNL-CL

CLG1; collagenase 2; HNC; matrix metallopeptidase 8; matrix metallopeptidase 8 (neutrophil collagenase); matrix metalloproteinase 8; matrix metalloproteinase 8 (neutrophil collagenase); Matrix metalloproteinase-8; MMP-8; MMP8; Neutrophil collagenase; PMN leukocyte collagenase; PMNL collagenase; PMNL-CL