MTAP (E5R1I) Rabbit Monoclonal Antibody (BSA and Azide Free)#73819,Cell Signaling Technology (CST),73819

MTAP is an enzyme that is essential for the salvage pathway for both adenine and methionine synthesis. MTAP catalyzes the cleavage of 5’-methylthioadenosine into adenine and 5-methylthio-D-ribose-1-phosphate. Adenine is then used to generate AMP whereas 5-methylthio-D-ribose-1-phosphate is converted into methionine (1,2). MTAP is expressed in all normal cells and tissues, although frequently lost in different human tumors, including pancreatic adenocarcinoma, neuroendocrine tumors, non-small cell lung carcinoma, and breast carcinoma. MTAP is usually codeleted with p16 (cdkN2a/ARF) (3-5). MTAP overexpression in breast cancer cells inhibits their ability to form colonies in soft agar, thereby implicating its function as a tumor suppressor (6).Backlund, P.S. and Smith, R.A. (1981)J Biol Chem256, 1533-5.Backlund, P.S. et al. (1982)J Biol Chem257, 4196-202.Dreyling, M.H. et al. (1998)Genes Chromosomes Cancer22, 72-8.Zhang, H. et al. (1996)Cancer Genet Cytogenet86, 22-8.Illei, P.B. et al. (2003)Clin Cancer Res9, 2108-13.Christopher, S.A. et al. (2002)Cancer Res62, 6639-44.Alternate Names5'-methylthioadenosine phosphorylase; BDMF; c86fus; DMSFH; DMSMFH; epididymis luminal protein 249; epididymis secretory sperm binding protein; HEL-249; LGMBF; MeSAdo phosphorylase; methylthioadenosine phosphorylase; MSAP; MTA phosphorylase; MTAP; MTAPase; S-methyl-5'-thioadenosine phosphorylase

5'-methylthioadenosine phosphorylase; BDMF; c86fus; DMSFH; DMSMFH; epididymis luminal protein 249; epididymis secretory sperm binding protein; HEL-249; LGMBF; MeSAdo phosphorylase; methylthioadenosine phosphorylase; MSAP; MTA phosphorylase; MTAP; MTAPase; S-methyl-5'-thioadenosine phosphorylase