Malic Enzyme 2 (E1N3E) Rabbit Monoclonal Antibody#15506,Cell Signaling Technology (CST),15506

Malic enzymes catalyze oxidative decarboxylation of malate to pyruvate (1). The malic enzyme family in mammalian cells includes the cytosolic malic enzyme 1 (ME1) and two mitochondrial malic enzymes (ME2 and ME3) (1, 2). ME1 and ME2 are critical for tumor cell growth and their expression is repressed by tumor suppressor p53 (2). Reduced expression of ME1 and ME2 reciprocally increases the levels and activation of p53, promoting p53-mediated senescence (2). Research studies show ME3 is essential for the survival of pancreatic ductal adenocarcinoma following genomic deletion ofME2(3). Deletion ofME3is lethal toME2-null cancer cells, which has been suggested to provide a potential therapeutic opportunity using collateral lethality (3, 4).Pongratz, R.L. et al. (2007)J Biol Chem282, 200-7.Jiang, P. et al. (2013)Nature493, 689-93.Dey, P. et al. (2017)Nature542, 119-23.Muller, F.L. et al. (2015)Trends Cancer1, 161-73.Alternate Namesmalate dehydrogenase (oxaloacetate-decarboxylating); Malic enzyme 2; malic enzyme 2, NAD(+)-dependent, mitochondrial; MAOM; ME2; NAD-dependent malic enzyme, mitochondrial; NAD-ME; ODS1; pyruvic-malic carboxylase

malate dehydrogenase (oxaloacetate-decarboxylating); Malic enzyme 2; malic enzyme 2, NAD(+)-dependent, mitochondrial; MAOM; ME2; NAD-dependent malic enzyme, mitochondrial; NAD-ME; ODS1; pyruvic-malic carboxylase