Max (E6F6Y) Rabbit Monoclonal Antibody#17471,Cell Signaling Technology (CST),17471

Members of the Myc/Max/Mad network function as transcriptional regulators with roles in various aspects of cell behavior, including proliferation, differentiation, and apoptosis (1). These proteins share a common basic-helix-loop-helix-leucine zipper (bHLH-Zip) motif required for dimerization and DNA binding. Max was originally discovered based on its ability to associate with c-Myc and was found to be required for the ability of Myc to bind DNA and activate transcription (2). Subsequently, Max has been viewed as a central component of the transcriptional network, forming homodimers as well as heterodimers with other members of the Myc and Mad families (1). The association between Max and either Myc or Mad can have opposing effects on transcriptional regulation and cell behavior (1). The Mad family consists of four related proteins: Mad1, Mad2 (Mxi1), Mad3, and Mad4, and the more distantly related members of the bHLH-ZIP family, Mnt and Mga. Like Myc, the Mad proteins are tightly regulated with short half-lives. In general, Mad family members interfere with Myc-mediated processes, such as proliferation, transformation, and prevention of apoptosis by inhibiting transcription (3,4).Baudino, T.A. and Cleveland, J.L. (2001)Mol Cell Biol21, 691-702.Blackwood, E.M. and Eisenman, R.N. (1991)Science251, 1211-7.Henriksson, M. and Lüscher, B. (1996)Adv Cancer Res68, 109-82.Grandori, C. et al. (2000)Annu Rev Cell Dev Biol16, 653-99.Alternate NamesBHLHD4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; Class D basic helix-loop-helix protein 4; helix-loop-helix zipper protein; MAX; MGC10775; MGC11225; MGC18164; MGC34679; MGC36767; MYC associated factor X; Myc-associated factor X; orf1; Protein max

BHLHD4; bHLHd5; bHLHd6; bHLHd7; bHLHd8; Class D basic helix-loop-helix protein 4; helix-loop-helix zipper protein; MAX; MGC10775; MGC11225; MGC18164; MGC34679; MGC36767; MYC associated factor X; Myc-associated factor X; orf1; Protein max