Melanocortin Receptor Antibody Explorer Kit,Alomone Labs,AK-565_KIT

Alomone Labs is pleased to offer theMelanocortin Receptor Antibody Explorer Kit(#AK-565). The Explorer Kit contains melanocortin receptor antibodies, ideal for screening purposes.

Platform ID

BAB341837892

Alomone Labs

Headquarters

PO Box 4287, Jerusalem 91042, Israel

Contact

Tel: +972-2-587-2202
Fax: +972-2-587-1101

Product Specifications
Scientific Background

Specifications

NameMelanocortin Receptor Antibody Explorer Kit
Cat. No.AK-565_KIT
Regulatory StatusResearch Use Only

Scientific Background

The melanocortin signaling system plays a role in many physiological outcomes such as skin pigmentation, food intake, sexual behavior and more. Melanocortin receptors (MCRs) 1 through 5, belong to the superfamily of G-protein coupled receptors, and mediate the effects of five different peptides: ACTH, α-MSH, β-MSH and γ-MSH. In addition, this system has endogenous antagonists: agouti and AGRP. Agouti inhibits MCR1 and MCR4, while AGRP antagonizes MCR3 and MCR4. These two antagonists, when overexpressed in mice, give rise to obese animals, and in some cases, obese and diabetic subjects. 1

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