Merlin (phospho Ser518) antibody,Genetex,GTX22478

Host

Rabbit

Reactivity

Mouse

Application

WB ICC/IF IHC-P ELISA Multiplexing

Conjugate

Unconjugated

Platform ID

BAB988117644

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameMerlin (phospho Ser518) antibody
Cat. No.GTX22478
Gene ID (Entrez)4771
HostRabbit
IsotypeIgG
ReactivityMouse
ConjugationUnconjugated
ApplicationWB ICC/IF IHC-P ELISA Multiplexing
ClonalityPolyclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetNF2
ImmunogenHuman NF2 (Merlin) phospho-peptide corresponding to a region of the human protein surrounding S518 and conjugated to KLH.
PurityPurified by antigen-affinity chromatography.From serum
Appearance/FormLiquid
Formulation20mM Potassium Phosphate, 150mM NaCl,0.01% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The recently isolated neurofibromatosis 2 tumor suppressor gene encodes a 595 amino acid protein (Merlin). The protein product Merlin, named for its relatedness to the ezrin, radixin and moesin (ERM) family of proteins, is a tumor suppressor whose absence results in the occurrence of multiple tumors of the nervous system, particularly schwannomas and meningiomas. Merlin's similarity to ERMs suggests that it might share functions, acting as a link between cytoskeletal components and the cell membrane. The NF2 protein is highly expressed in human fibroblasts and detected as a single band of about 75kD. This antibody is specific for the phosphorylated form of human NF2 (Merlin).

Synonyms

neurofibromin 2 , ACN , BANF , SCH

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