Monoclonal Anti-Duocarmycin Antibody, Rabbit IgG (M1E06),Acro Biosystems,DUN-MY2287
Monoclonal Anti-Duocarmycin Antibody, Rabbit IgG (M1E06) is a Rabbit monoclonal antibody recombinantly expressed from HEK293 cells.
Conjugate
Unconjugated
Platform ID
BAB716100458
Acro Biosystems
Contact
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Product Specifications
Specifications
NameMonoclonal Anti-Duocarmycin Antibody, Rabbit IgG (M1E06)
Cat. No.DUN-MY2287
IsotypeRabbit IgG | Rabbit Kappa
ConjugationUnconjugated
Clone NumberM1E06
ImmunogenDuocarmycin-BSA
FormulationLyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.
Please contact us for customized product forms or formulations.
ReconstitutionPlease refer to the Certificate of Analysis (CoA) for specific instructions.
For best performance, we strongly recommend following the reconstitution protocol provided in the CoA.
StorageDuocarmycin, a DNA minor groove-binding alkylating agent, acts as a payload in antibody-drug conjugates (ADCs) by selectively targeting AT-rich regions of DNA. It forms covalent bonds with the N3 position of adenine, inducing strand breaks and apoptosis through S-phase cell cycle arrest . This mechanism bypasses multidrug resistance pathways, making it potent against aggressive tumors.
Category Paths
- Products>Anti-payload Antibodies
- Products>Primary Antibodies>Monoclonal Antibodies
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