Monoclonal Anti-HRSV F Antibody, Human IgG1 (AM14) (MALS verified),Acro Biosystems,HRF-S367
Monoclonal Anti-HRSV F Antibody, Human IgG1 (AM14) is a chimeric monoclonal antibody recombinantly expressed from CHO, which combines the variable region of a mouse monoclonal antibody with Human constant domain.
Host
Mouse
Application
ELISA
Conjugate
Unconjugated
Platform ID
BAB717299882
Acro Biosystems
Contact
Tel: +1 800-810-0816
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Product Specifications
Specifications
NameMonoclonal Anti-HRSV F Antibody, Human IgG1 (AM14) (MALS verified)
Cat. No.HRF-S367
HostMouse
IsotypeHuman IgG1 | Human Kappa
ConjugationUnconjugated
ApplicationELISA
Working Dilutions0.2-63 ng/mL
Clone NumberAM14
Purity90% as determined by SDS-PAGE.
95% as determined by SEC-MALS.
FormulationLyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.
Please contact us for customized product forms or formulations.
ReconstitutionPlease refer to the Certificate of Analysis (CoA) for specific instructions.
For best performance, we strongly recommend following the reconstitution protocol provided in the CoA.
StorageHuman respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. The RSV fusion glycoprotein (RSV F) is the principal target of RSV neutralizing antibodies in human sera. The RSV F is a type I viral fusion protein synthesized as inactive, single-chain polypeptides that assemble into trimers. RSV F fuses the viral and host cell membranes by irreversible protein refolding from the labile prefusion conformation to the stable post-fusion conformation. Antibody AM14 has a uniquely trimer-specific and and neutralizing activity. It recognizes a quaternary epitope that spans two protomers and includes a region that undergoes extensive conformational changes in the pre- to postfusion F transition. The specificity of the potent RSV neutralizing antibody AM14 makes it a useful reagent for probing or isolating the cleaved trimeric state of prefusion F.
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
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