Monoclonal Anti-Payload PBD Antibody, Rabbit IgG (M1D08),Acro Biosystems,PAD-MY2221
Monoclonal Anti-Payload PBD Antibody, Rabbit IgG (M1D08) is a Rabbit monoclonal antibody recombinantly expressed from HEK293 cells.
Application
ELISA
Conjugate
Unconjugated
Platform ID
BAB779681189
Acro Biosystems
Contact
Tel: +1 800-810-0816
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Product Specifications
Specifications
NameMonoclonal Anti-Payload PBD Antibody, Rabbit IgG (M1D08)
Cat. No.PAD-MY2221
IsotypeRabbit IgG | Rabbit Kappa
ConjugationUnconjugated
ApplicationELISA
Working Dilutions0.06-10000 ng/mL
Clone NumberM1D08
ImmunogenPBD-BSA
FormulationLyophilized from a 0.22 μm-filtered solution in PBS (pH 7.4), with trehalose as protectant.
Please contact us for customized product forms or formulations.
ReconstitutionPlease refer to the Certificate of Analysis (CoA) for specific instructions.
For best performance, we strongly recommend following the reconstitution protocol provided in the CoA.
StoragePyrrolobenzodiazepine (PBD) dimer, is a new generation of cytotoxic payload used in antibody-drug conjugates (ADCs). The PBD dimer binds to the minor groove of DNA to form effective cytotoxic DNA interstrand crosslinks, which can block cell division and kill cancer cells. This mechanism of action utilizes a completely different cellular target from that of tubulin inhibitors, as well as a different DNA damage pattern from other DNA-targeting payloads. Anti-PBD antibody is a rabbit monoclonal antibody specially reacts with PBD, which is more sensitive than mouse antibody. The anti-PBD antibody is a useful reagent in PK assay to determine conjugated antibodies.
Category Paths
- Products>Anti-payload Antibodies
- Products>Primary Antibodies>Monoclonal Antibodies
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