Mouse Diablo homolog, mitochondrial (DIABLO) ELISA Kit,Abbkine,KTE71285
• Do not mix components from different kit lots or use reagents beyond the kit expiration date.• Allow all reagents to warm to room temperature for at least 30 minutes before opening.• Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination. • Unused wells must be kept desiccated at 4 °C in the sealed bag provided.• Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.• It is recommended that all samples and standards be assayed in duplicate or triplicate.
Platform ID
BAB644123759
Abbkine
Contact
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Specifications
Scientific Background
DIABLO encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in DIABLO is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms
DIABLO; hCG_1782202; DIABLO-S; FLJ10537; FLJ25049; SMAC; SMAC3; 0610041G12Rik; diablo; direct IAP-binding protein with low pI; mitochondrial Smac protein; second mitochondria-derived activator of caspase
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