Mouse IgG2b Isotype Control (Clone MPC-11-LALA-PG) – Recombinant In vivo Purified No Carrier Protein,Leinco,I-1321

Clone MPC-11 is a recombinant mouse IgG2b, kappa isotype control. Originally derived from a BALB/c mouse plasmacytoma, the variable regions of this clone possess no known functional specificity or reactivity toward mammalian antigens. This makes it an ideal negative control for establishing accurate baselines in flow cytometry, immunohistochemistry, and functional assays by accounting for non-specific background signal. Advanced Fc Engineering: To maximize assay precision and eliminate false positives in sensitive applications, this recombinant version of Clone MPC-11 features an engineered Mouse IgG2b Fc region containing a LALAPG mutation. Effector Silencing: The LALAPG modification effectively silences Fc-mediated effector functions which makes it perfect to be used with similar primary antibodies when needing a control. Background Elimination: It eliminates non-specific background binding to Fcγ receptors (FcγR) and prevents complement activation, providing a truly "inert" control for both in vitro and in vivo studies.