Mouse Vasohibin-1 (VASH1) ELISA Kit,Abbkine,KTE70031
• Do not mix components from different kit lots or use reagents beyond the kit expiration date.• Allow all reagents to warm to room temperature for at least 30 minutes before opening.• Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination. • Unused wells must be kept desiccated at 4 °C in the sealed bag provided.• Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.• It is recommended that all samples and standards be assayed in duplicate or triplicate.
Platform ID
BAB198758786
Abbkine
Contact
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Specifications
Scientific Background
VASH2 deduced 355-amino acid protein shares 52.5% amino acid identity with VASH1 and 97.5% amino acid identity with mouse Vash2. VASH2 expression at embryonic weeks 6 to 12 in human heart, brain, kidney, lung, muscle, and whole embryo. RT-PCR analysis detected low levels of VASH2 expression in HUVECs and aortic endothelial cells. VASH2 expression in cell lines was not inducible by VEGF, FGF2, or PMA, all of which can induce VASH1 expression. However, in an in vivo mouse model, Vash2 was induced in embryonic brain transfected with VEGF. Immunohistochemistry showed that VASH2 and VASH1 were present in vessels from 20-week human embryonic lung.VASH2 has antiangiogenic activity. In addition, VASH2 inhibited network formation by HUVECs.
Synonyms
VASH1; KIAA1036;
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