N6-methyladenosine / m6A Rabbit mAb- ABclonal,ABclonal,A19841

Reactivity

Species independent

Application

DB, IF/ICC, ELISA, meRIP, Nucleotide Array

Platform ID

BAB407127687

ABclonal

Headquarters

500W Cummings Park, Ste. 6500 Woburn, MA 01801

ABclonal

Contact

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Fax:

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameN6-methyladenosine / m6A Rabbit mAb- ABclonal
Cat. No.A19841
RRIDAB_2862753
IsotypeIgG
ReactivitySpecies independent
ApplicationDB, IF/ICC, ELISA, meRIP, Nucleotide Array
Working DilutionsDB:1:500 - 1:2000 | IF/ICC:1:50 - 1:200 | ELISA:Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. | meRIP:1:50 - 1:200
Clone NumberARC5003-10
Molecular WeightRefer to figures
ImmunogenChemical compounds corresponding to N6-methyladenosine / m6A.
PurityProtein A
Appearance/FormLiquid
StorageStore at -20℃. Avoid freeze / thaw cycles.; Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Regulatory StatusResearch Use Only

Scientific Background

Discovered in the 1970s, m6A is the most prevalent internal modification in polyadenylated mRNAs and long non-coding RNAs (lncRNAs) in higher eukaryotes. m6A is widely conserved among eukaryotic species that range from yeast, plants, flies to mammals, as well as among viral RNAs with a nuclear phase. The m6A-based modification is associated with a well-defined RNA motif, RRACH (R: A/G, H: A/C/U). As a representative of the epitranscriptome, m6A mRNA modifications participate in many vital activities in the cell, including stem cell self-renewal and differentiation, mRNA transcription, alternative splicing, nuclear export, translation, degradation, and microRNA processing. These processes determine the expression or inactivation of specific genes, which is vital for growth and development.(PMID: 30416848; PMID: 24662220; PMID: 30429466)

Synonyms

N6-methyladenosine; m6A; N6-methyladenosine / m6A

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