NAK / TBK1 antibody [108A429],Genetex,GTX12116

Host

Mouse

Reactivity

Human, Mouse, Rat, Bovine, Dog

Application

WB ICC/IF IHC-P

Conjugate

Unconjugated

Platform ID

BAB271637811

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameNAK / TBK1 antibody [108A429]
Cat. No.GTX12116
Gene ID (Entrez)29110
HostMouse
IsotypeIgG1
ReactivityHuman, Mouse, Rat, Bovine, Dog
ConjugationUnconjugated
ApplicationWB ICC/IF IHC-P
ClonalityMonoclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetTBK1
ImmunogenA synthetic peptide corresponding to amino acids 563-577 (YYQFKKDKAERRLAYC) of human NAK / TBK1 was used as immunogen for this antibody (NP_037386).
PurityProtein G purified
Appearance/FormLiquid
FormulationPBS,0.05% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. [provided by RefSeq]

Synonyms

TANK binding kinase 1 , FTDALS4 , IIAE8 , NAK , T2K

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