NF-κB p65 Antibody (YA6184),MedChemexpress,HY-P86492

NFkB p65 (RELA/p65) is a core component of the NF-kappa-B transcription factor family, predominantly forming the heterodimeric RELA-NFKB1 complex with NFKB1/p50 as the most abundant NF-kappa-B variant. This pleiotropic factor binds to kappa-B sites in target gene DNA to regulate diverse biological processes including inflammation, immunity, cell differentiation, and tumorigenesis. Inactive cytoplasmic NF-kappa-B complexes are retained by I-kappa-B inhibitors until IKK-mediated phosphorylation triggers their nuclear translocation for transcriptional activation. RELA contributes weak DNA-binding activity to the complex while also modulating chromatin accessibility for indirect gene regulation. It cooperates with DDX1 at NF-kappa-B promoter regions and is essential for cytokine expression in T-cells (by similar). The RELA-RELA homodimer mediates invasin-induced IL-8 expression and serves as a key regulator of IFN response during SARS-CoV-2 infection.

RELA; NFKB3; Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3