NHE-1 antibody,Genetex,GTX85047

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB IHC-P ELISA

Conjugate

Unconjugated

Platform ID

BAB948003115

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameNHE-1 antibody
Cat. No.GTX85047
Gene ID (Entrez)6548
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB IHC-P ELISA
ClonalityPolyclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetSLC9A1
ImmunogenNhe-1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of the human Nhe-1.The immunogen is located within the last 50 amino acids of Nhe-1.
PurityPurified by antigen-affinity chromatography
Appearance/FormLiquid
FormulationPBS,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The Na+/H+ antiporter (Nhe-1) is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells and is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, and tumor promoters. Nhe-1 acts as an anchor for actin filaments to control the integrity of the cortical cytoskeleton. This occurs through a previously unrecognized structural link between Nhe-1 and the actin-binding proteins ezrin, radixin, and moesin, collectively referred to as ERM proteins. A structural role for Nhe-1 has been proposed in regulating the cortical cytoskeleton that is independent of its function as an ion exchanger. It is also thought that Nhe-1 play a role in hypertension. At least two isoforms of Nhe-1 are known to exist.

Synonyms

solute carrier family 9 member A1 , APNH , LIKNS , NHE-1 , NHE1 , PPP1R143

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