NOX2 / gp91phox antibody,Genetex,GTX12024

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB IHC-P

Conjugate

Unconjugated

Platform ID

BAB520063567

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background

Specifications

NameNOX2 / gp91phox antibody
Cat. No.GTX12024
Gene ID (Entrez)1536
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB IHC-P
ClonalityPolyclonal
Concentration500 μg/ml (Please refer to the vial label for the specific concentration.)
TargetCYBB
ImmunogenA synthetic peptide corresponding to a sequence in the middle region of human NOX2(442-459aa YWLCRDTHAFEWFADLLQ), identical to the related rat and mouse sequences.
PurityPurified by antigen-affinity chromatography
Appearance/FormLiquid
Formulation0.1% Na₂HPO₄, 0.45% NaCl, 2.5% BSA,0.025% Thimerosal, 0.025% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]

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