NOX2 / gp91phox antibody, Internal,Genetex,GTX88404

Host

Goat

Reactivity

Human

Application

IHC-P

Conjugate

Unconjugated

Platform ID

BAB645492068

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameNOX2 / gp91phox antibody, Internal
Cat. No.GTX88404
Gene ID (Entrez)1536
HostGoat
IsotypeIgG
ReactivityHuman
ConjugationUnconjugated
ApplicationIHC-P
ClonalityPolyclonal
Concentration0.50 mg/ml (Please refer to the vial label for the specific concentration.)
TargetCYBB
ImmunogenPeptide with sequence C-SYLNFARKRIKNP, from the internal region of the protein sequence according to NP_000388.2.
PurityPurified by ammonium sulphate precipitation followed by antigen affinity chromatography
Appearance/FormLiquid
FormulationTBS, 0.5% BSA,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]

Synonyms

cytochrome b-245 beta chain , AMCBX2 , CGD , GP91-1 , GP91-PHOX , GP91PHOX , IMD34 , NOX2 , p91-PHOX

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