NTH1 Antibody (YA1435),MedChemexpress,HY-P81690
NTH1 Antibody (YA1435) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NTH1.
Host
Rabbit
Reactivity
Human
Application
WB,ICC/IF
Conjugate
Non-conjugated
Platform ID
BAB446557948
Suppliers
(1)Biomedical Life sciences
MedChemexpress
Master of Bioactive Molecules
Contact
Tel: 609-228-6898
Fax: 609-228-5909
Email:
Specifications
Verification Image
Scientific Background
NTH1 is a bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that initiates base excision repair (BER), the primary pathway for repairing oxidative DNA damage. Its DNA N-glycosylase activity cleaves the N-glycosidic bond to excise damaged bases, generating an AP site, while the AP-lyase activity cleaves the 3' phosphodiester bond via β-elimination. It primarily recognizes and repairs oxidative pyrimidine damage but also exhibits 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity, preferentially targeting lesions opposite guanine residues. Notably, it processes nucleosome-embedded lesions without requiring or inducing nucleosome disruption.
Synonyms
FAP3; NTH1; OCTS3; hNTH1
Category Paths
- Products>Primary Antibodies>Monoclonal Antibodies
- Products>Primary Antibodies>Recombinant Antibodies
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