NUMB antibody,Genetex,GTX30689

Host

Rabbit

Reactivity

Human, Mouse, Rat, Chicken

Application

WB ICC/IF

Conjugate

Unconjugated

Platform ID

BAB310918947

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameNUMB antibody
Cat. No.GTX30689
Gene ID (Entrez)18222
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat, Chicken
ConjugationUnconjugated
ApplicationWB ICC/IF
ClonalityPolyclonal
Concentration3.5 mg/ml (Please refer to the vial label for the specific concentration.)
TargetNumb
ImmunogenA synthetic peptide made to a C-terminal region of mouse NUMB (between residues 600-653). [UniProt# Q9QZS3]
PurityPurified by antigen-affinity chromatography
Appearance/FormLiquid
FormulationTris-Glycine, 150mM NaCl,0.05% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.

Synonyms

NUMB endocytic adaptor protein , Nb

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