NUP153 (E3N3Y) Rabbit Monoclonal Antibody#36936,Cell Signaling Technology (CST),36936

The nuclear pore complex (NPC) is a multi-subunit protein channel that spans the nuclear envelope and is responsible for the nucleocytoplasmic trafficking of RNA, proteins, and ribonucleoproteins (1,2). Nucleoporin 153 kDa (NUP153) protein functions as a scaffolding element that recruits other proteins to form the “nuclear basket” on the nuclear side of the pore complex. NUP153 is essential for normal nucleocytoplasmic transport of proteins and mRNAs and is critical for the quality control and retention of unspliced mRNAs in the nucleus (1,2). NUP153 is a potential DNA-binding subunit of the NPC and is important for proper regulation of embryonic stem cell pluripotency and differentiation (1,3). Depletion of NUP153 leads to derepression of developmental genes and induction of early differentiation. NUP153 binds to Nucleoporin-Associated Regions (NARs) that are found near the transcriptional start sites of developmental genes and mediates recruitment of polycomb repressor complex 1 (PRC1) to repress transcription in embryonic stem cells (3).Raices, M. and D'Angelo, M.A. (2017)Curr Opin Cell Biol46, 26-32.Xu, S. and Powers, M.A. (2009)Semin Cell Dev Biol20, 620-30.Jacinto, F.V. et al. (2015)Genes Dev29, 1224-38.Alternate Names153 kDa nucleoporin; B130015D15Rik; C88147; NU153; nuclear pore complex protein Nup153; Nucleoporin 153; Nup153

153 kDa nucleoporin; B130015D15Rik; C88147; NU153; nuclear pore complex protein Nup153; Nucleoporin 153; Nup153