Nanos2 antibody,Genetex,GTX85392

Host

Rabbit

Reactivity

Human, Mouse, Rat

Application

WB ELISA

Conjugate

Unconjugated

Platform ID

BAB199827239

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameNanos2 antibody
Cat. No.GTX85392
Gene ID (Entrez)339345
HostRabbit
IsotypeIgG
ReactivityHuman, Mouse, Rat
ConjugationUnconjugated
ApplicationWB ELISA
ClonalityPolyclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetNANOS2
ImmunogenNanos2 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of the human Nanos2.The immunogen is located within the last 50 amino acids of Nanos2.
PurityPurified by antigen-affinity chromatography
Appearance/FormLiquid
FormulationPBS,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

Nanos is a zinc-finger containing, RNA-binding protein that has been implicated in germ cell development in both invertebrates and vertebrates. In drosophila, Nanos represses apoptosis during development to ensure proper germ-line development. Unlike Nanos1 whose expression in mice is dispensable, the Nanos2 and Nanos3 proteins are required for germ cell development. Nanos2- primordial germ cells (PGCs) die only in the male gonads and show no defects in females, while Nanos3- PGCs are lost during the migration stage regardless of sex. Nanos2 and Nanos3 have distinct expression patterns during embryo development, suggesting that these two proteins do not have redundant functions. However, expression of Nanos2 can at least partially replace Nanos3 function in a Nanos3- background. Nanos3 expression can not rescue Nanos2- defects. This Nanos2 antibody will not cross-react with either Nanos 1 or Nanos3.

Synonyms

nanos C2HC-type zinc finger 2 , NOS2 , ZC2HC12B

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