NeuN (D4G4O) Feline Chimeric Monoclonal Antibody#41048,Cell Signaling Technology (CST),41048

NeuN (D4G4O) Feline Chimeric Monoclonal Antibody recognizes endogenous levels of total NeuN protein.

Host

Feline

Reactivity

Human, Mouse, Rat, Monkey

Application

Immunofluorescence (Frozen): 1:50 - 1:200

Platform ID

BAB489876684

Cell Signaling Technology (CST)

Headquarters

3 Trask Lane Danvers, MA 01923

Cell Signaling Technology (CST)

Contact

Tel: 877-616-2355,978-867-2388
Fax: 877-616-2355

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameNeuN (D4G4O) Feline Chimeric Monoclonal Antibody#41048
Cat. No.41048
Accession NumberA6NFN3, 146713
Gene ID (Entrez)146713
HostFeline
SensitivityEndogenous
ReactivityHuman, Mouse, Rat, Monkey
ApplicationImmunofluorescence (Frozen): 1:50 - 1:200
Immunogenchimeric
FormulationSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
StorageSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C.Do not aliquot the antibody.
Regulatory StatusResearch Use Only

Scientific Background

Neuronal nuclei (NeuN, Fox-3, RBFOX3) is a nuclear protein expressed in most post-mitotic neurons of the central and peripheral nervous systems. NeuN is not detected in Purkinje cells, sympathetic ganglion cells, Cajal-Retzius cells, INL retinal cells, inferior olivary, or dentate nucleus neurons (1). This neuronal protein was originally identified by immunoreactivity with a monoclonal antibody also called NeuN. Using MS analysis, NeuN was later identified as theFox-3gene product. Fox-3 contains an RNA recognition motif and functions as a splicing regulator (2). Fox-3 regulates alternative splicing of NumB, promoting neuronal differentiation during development (3).Mullen, R.J. et al. (1992)Development116, 201-11.Kim, K.K. et al. (2009)J Biol Chem284, 31052-61.Kim, K.K. et al. (2013)J Cell Biol200, 443-58.Alternate NamesFLJ56884; FLJ58356; fox-1 homolog C; Fox-3; FOX3; hCG_1776007; hexaribonucleotide binding protein 3; HRNBP3; NEUN; NeuN antigen; neuronal nuclei; Neuronal nuclei antigen; RBFOX3; RFOX3; RNA binding fox-1 homolog 3; RNA binding protein fox-1 homolog 3; RNA binding protein, fox-1 homolog 3

Synonyms

FLJ56884; FLJ58356; fox-1 homolog C; Fox-3; FOX3; hCG_1776007; hexaribonucleotide binding protein 3; HRNBP3; NEUN; NeuN antigen; neuronal nuclei; Neuronal nuclei antigen; RBFOX3; RFOX3; RNA binding fox-1 homolog 3; RNA binding protein fox-1 homolog 3; RNA binding protein, fox-1 homolog 3

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