Neuropeptide Y Receptor Antibody Explorer Kit,Alomone Labs,AK-540_KIT

Neuropeptide Y (NPY) is a 36-amino acid peptide neurotransmitter in the central (CNS) and peripheral nervous systems. 1 It belongs to the NPY family, together with the peptide YY (PYY) and the pancreatic polypeptide (PP). NPY is involved in regulation of a broad range of homeostatic functions such as eating behavior, hypertension, and reproduction. 2 NPY exerts its effects via five receptor subtypes known as the neuropeptide Y receptors (NPYR): Y 1 (NPY 1 R), Y 2 (NPY 2 R), Y 4 (NPY 4 R), Y 5 (NPY 5 R) and Y 6 (NPY 6 R). 2 Four of these, Y 1 , Y 2 , Y 4 , and Y 5 , are expressed in humans. 2 The NPY receptors belong to the G protein-coupled receptor superfamily whose members share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus. Activation of these receptors by NPY produces effects on [Ca 2+ ] i , adenylate cyclase, and a number of ion channels. 3 Based on the high frequency and density of NPY receptors in steroid hormone-producing tumors, the NPY receptors might be of potential use in tumor management. 2