Neurotrophin Receptor Antibody Explorer Kit,Alomone Labs,AK-238_KIT

NGF was the first neurotrophin to be discovered more than 50 years ago. Three other proteins have been added to the list: BDNF , NT-3 and NT-4 (NT-4/5). These neurotrophins bind two groups of receptors. The p75 NGF receptor (p75 NTR ) is common to all four neurotrophins and is a member of the tumor necrosis factor receptor family. The tropomyosin-related kinase (Trk) receptors are receptor tyrosine kinases (RTKs) and three receptors form this family: TrkA , TrkB , and TrkC 1 . As mentioned above, p75 NTR binds to all neurotrophins with similar affinities while the Trk receptors are the ones to display the selectivity for the neurotrophins. TrkA is activated by NGF binding, TrkB by that of BDNF and NT-4, while TrkC is stimulated by the binding of NT-3 1 .