Nucleophosmin antibody [5E3],Genetex,GTX57555

Host

Mouse

Reactivity

Human

Application

WB ICC/IF IHC-P FCM

Conjugate

Unconjugated

Platform ID

BAB138356759

Genetex

Headquarters

2456 Alton Pkwy Irvine, CA 92606 USA

Genetex

Contact

Tel: 1-949-553-1900
Fax: 1-949-309-2888

Email:

[email protected]

Product Specifications
Scientific Background
Synonyms

Specifications

NameNucleophosmin antibody [5E3]
Cat. No.GTX57555
Gene ID (Entrez)4869
HostMouse
IsotypeIgG2b
ReactivityHuman
ConjugationUnconjugated
ApplicationWB ICC/IF IHC-P FCM
ClonalityMonoclonal
Concentration1 mg/ml (Please refer to the vial label for the specific concentration.)
TargetNPM1
ImmunogenThe clone 5E3 is derived from hybridization of mouse SP2/2 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human NPM protein.
PurityProtein G Purified
Appearance/FormLiquid
FormulationPBS, 10% Glycerol,0.02% Sodium azide
StorageStore as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Regulatory StatusResearch Use Only

Scientific Background

The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]

Synonyms

nucleophosmin 1 , B23 , NPM , NPM1 , nucleophosmin , Nucleophosmin

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