OX40L (D6K7R) Rabbit Monoclonal Antibody#59036,Cell Signaling Technology (CST),59036

OX40 (TNFRSF4, CD134) is a member of the tumor necrosis factor (TNF) receptor superfamily that regulates T cell activity and immune responses. The OX40 protein contains four cysteine rich domains, a transmembrane domain, and a cytoplasmic tail containing a QEE motif (1,2). OX40 is primarily expressed on activated CD4+ and CD8+ T-cells, while the OX40 ligand (OX40L, TNFSF4, CD252) is predominantly expressed on activated antigen presenting cells (3-7). The engagement of OX40 with OX40L leads to the recruitment of TNF receptor-associated factors (TRAFs) and results in the formation of a TCR-independent signaling complex. One component of this complex, PKCθ, activates the NF-κB pathway (2,8). OX40 signaling through Akt can also enhance TCR signaling directly (9). Research studies indicate that the OX40L-OX40 pathway is associated with inflammation and autoimmune diseases (10). Additional research studies show that OX40 agonists augment anti-tumor immunity in several cancer types (11,12).Croft, M. (2010)Annu Rev Immunol28, 57-78.So, T. and Croft, M. (2012)Front Immunol3, 133.Paterson, D.J. et al. (1987)Mol Immunol24, 1281-90.Mallett, S. et al. (1990)EMBO J9, 1063-8.Dürkop, H. et al. (1995)Br J Haematol91, 927-31.Godfrey, W.R. et al. (1994)J Exp Med180, 757-62.Al-Shamkhani, A. et al. (1997)J Biol Chem272, 5275-82.So, T. et al. (2011)Proc Natl Acad Sci U S A108, 2903-8.So, T. and Croft, M. (2013)Front Immunol4, 139.Gough, M.J. and Weinberg, A.D. (2009)Adv Exp Med Biol647, 94-107.Weinberg, A.D. et al. (2011)Immunol Rev244, 218-31.Linch, S.N. et al. (2015)Front Oncol5, 34.Alternate NamesCD134 ligand; CD134L; CD252; Glycoprotein Gp34; GP34; OX-40L; OX40 antigen ligand; OX40 ligand; OX40L; OX4OL; TAX transcriptionally-activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 (34kD); TNF superfamily member 4; TNFL4; TNFSF4; TNLG2B; tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor (ligand) superfamily, member 4; tumor necrosis factor ligand 2B; Tumor necrosis factor ligand superfamily member 4; tumor necrosis factor superfamily member 4; TXGP1

CD134 ligand; CD134L; CD252; Glycoprotein Gp34; GP34; OX-40L; OX40 antigen ligand; OX40 ligand; OX40L; OX4OL; TAX transcriptionally-activated glycoprotein 1; tax-transcriptionally activated glycoprotein 1 (34kD); TNF superfamily member 4; TNFL4; TNFSF4; TNLG2B; tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor (ligand) superfamily, member 4; tumor necrosis factor ligand 2B; Tumor necrosis factor ligand superfamily member 4; tumor necrosis factor superfamily member 4; TXGP1